The development of Scientific complementary metal oxide semiconductor (sCMOS) cameras can be considered a breakthrough technology in its own right. At their time of introduction in 2010, sCMOS cameras offered a combination of high sensitivity, fast frame rates, very low noise and wide field of view that addressed the needs of many scientific imaging applications. This was a major improvement on other cameras of the time based on CCD sensor technology. sCMOS cameras have since become an integral part of the experimental set-up of many important scientific discoveries. With that in mind, sCMOS is an enabling technology, along with other supporting equipment and techniques. In this article we look at some of the important developments since sCMOS was introduced.