Microscopy Developments with sCMOS Cameras

The development of Scientific complementary metal oxide semiconductor (sCMOS) cameras can be considered a breakthrough technology in its own right. At their time of introduction in 2010, sCMOS cameras offered a combination of high sensitivity, fast frame rates, very low noise and wide field of view that addressed the needs of many scientific imaging applications. This was a major improvement on other cameras of the time based on CCD sensor technology. sCMOS cameras have since become an integral part of the experimental set-up of many important scientific discoveries. With that in mind, sCMOS is an enabling technology, along with other supporting equipment and techniques. In this article we look at some of the important developments since sCMOS was introduced.

• CRIPSR and Gene Editing – Designer Genes
• Optogenetics – Illuminating the Inner Processes of the Brain
• Organoids – Providing a More Accurate Model of Complex Cell Function
• Super Resolution – What’s Happening Beyond the Diffraction Limit?
• Light Sheet – Is it all about the Beams?
• Expansion Microscopy – An Alternative Approach to Higher Resolution Imaging
• Adaptive Optics – Correcting Distortions to Enhance Resolution
• Clearing Tissues – Providing Clarity on Brain Function
• Deep Learning – Applying Machine Learning to Help Solve Complex Questions
• Dragonfly – High Speed Multi-modal Confocal System