Part of the Oxford Instruments Group

Photostimulation and Optogenetics Solutions

Photostimulation and Optogenetics enables precise optical manipulation of complex biological networks. More researchers are exploiting these techniques in fields as diverse as neural mapping, visual regeneration and vascular hypertension. Optogenetics allows observations that cannot be determined by other means at the organ, tissue and cellular levels.

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MicroPoint 4 and Mosaic 3 for Photostimulation and Optogenetics

MicroPoint 4

Precise Delivery of Laser-based Illumination
  • DNA damage - cancer research
  • Ablation - Damage and repair studies
  • FRAP and PA - cell dynamics
  • Uncaging - signaling
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Mosaic 3

Real-time, Multi-Region Illumination
  • Optophysiology/optogenetics
  • FRAP and PA - cell dynamics
  • Uncaging and signaling studies
  • Selective region imaging
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Matching Application Requirements

Illumination Power Required Type of Experiment Mosaic Micropoint Illumination Requirement Example Applications
Ablation Studies Pulsed Axotomy. Cut microtubules or cytoskeleton. Wound healing assays
DNA Damage Pulsed/CW DNA damage/repair, gene expression, developmental and cancer studies
Uncaging Pulsed/CW Determine function of biomolecules within the cell and/or organism context
FRAP/FLIP/FRET CW Observe protein dynamics, fusion and binding events. Cell compartmentalisation and localization
Photoswitching/Photoconversion CW Study the function of proteins and molecules within complex pathways
Phenotype Marking CW/LED Simultaneous multi-region photoactivation. Simultaneous photoactivation for identification and sorting​
User Defined Complex Regions of Illumination CW/LED Define complex regions of interest: target specific cell structures, groups of cells or tissues
Optophysiology and Optogenetics CW/LED Cell & Neuronal signalling, opsin controlled secondary messengers e.g. Ca2+. Optically controlled protein switching. Signalling cascades. Combine with electrophysiology​


- Not Suitable
- Suitable for Some Applications
- Partially Suitable
- Recommended


Pulsed - A pulsed dye laser provides a wide range of wavelengths and high energy at up to 20 pulses per second. While a solid state pulsed laser delivers higher peak power at higher repitition rates.

CW - MicroPoint can be used with CW (continuous wave) lasers for scanned FRAP and other high power density applications. Mosaic can be coupled with Andor's HLE for high power bleaching applications across the visible spectrum.

LED - LED light sources coupled with Mosaic provide illumination powers suitable for many optogenetic probes e.g. ChRh, light-induced dimerization systems and many others.