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Dragonfly Confocal: 100 + Publications. Delivering Science with Impact

Since its launch, more than 100 papers have been published in high profile journals using Dragonfly. Dragonfly is a unique spinning disk confocal system that revolutionised the way imaging systems are perceived.

Before Dragonfly, there was no instrument compatible with live-cell imaging that could deliver deep-tissue imaging, as well as single-molecule localisation microscopy.

Over
100
Publications

Spanning
17
Countries

Research that makes an Impact

At Andor it matters to us that the products we develop make a real difference to our customers and contribute significantly to their research.  We were born out of Queen’s University and have never forgotten our roots.  It excites us that the Dragonfly platform is being widely used in papers published in high-impact journals like Nature, Neuron, Journal of Cell Biology and more.

64% of Dragonfly papers are published in journals with an impact factor of > 5

Multidisciplinary Research

Dragonfly is much more than a high-speed confocal. TIRF, SRRF, and powerful laser-based widefield illumination can deliver super-resolved understanding of processes and place them in the context of whole tissues and organisms. Combined with Imaris, market leading 3D analysis software, our workflows address a broad range of disciplines with a single solution.

Disease Research

Clinical & Drug Studies

Technique Development

Membrane Dynamcs

Neuroscience

Mitochondria

Cell Division

Stem Cells

Actin

Centrosomes & Cilia

DNA Damage

Selected Publications

Title Journal
The nucleoskeleton protein IFFO1 immobilizes broken DNA and suppresses chromosome translocation during tumorigenesis Nature Cell Biology
Long-Term Potentiation Requires a Rapid Burst of Dendritic Mitochondrial Fission during Induction Neuron
Melatonin promotes human oocyte maturation and early embryo development by enhancing clathrin‐mediated endocytosis J Pineal Res.
A jumbo phage that forms a nucleus-like structure evades CRISPR–Cas DNA targeting but is vulnerable to type III RNA-based immunity Nature Microbiology
Multiplexed 3D super-resolution imaging of whole cells using spinning disk confocal microscopy and DNA-PAINT Nature Communications
Building sensory axons: Delivery and distribution of NaV1.7 channels and effects of inflammatory mediators Science Advances
TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts Nature Communications
MRE11 UFMylation promotes ATM activation Nucleic Acids Research
PDZD8 mediates a Rab7-dependent interaction of the ER with late endosomes and lysosomes PNAS
INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division Journal Cell Biology
A Contraction Stress Model of Hypertrophic Cardiomyopathy due to Sarcomere Mutations Stem Cell Reports
Glia Promote Synaptogenesis through an IQGAP PES-7 in C. elegans Cell Reports
Nephron progenitor commitment is a stochastic process influenced by cell migration elife
A nuclear role for the DEAD-box protein Dbp5 in tRNA export elife
Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates elife
SRRF-stream imaging of optogenetically controlled furrow formation shows localized and coordinated endocytosis and exocytosis mediating membrane remodeling ACS Synth. Biol
In vivo Environment Swiftly Restricts Human Pancreatic Progenitors Toward Mono-Hormonal Identity via a HNF1A/HNF4A Mechanism Frontiers in Cell and Developmental Biology
Two distinct actin filament populations have effects on mitochondria, with differences in stimuli and assembly factors Journal Cell Science
Applications of Nanocellulose/Nanocarbon Composites: Focus on Biotechnology and Medicine Nanomaterials
Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling Scientific Reports

Recent Webinars

 

We presented actual membrane trafficking events captured using Andor’s Super-Resolution Radial Fluctuation (SRRF-Stream) implemented via the highly sensitive iXon camera. Andor´s imaging technology offered new insights on the role of PI3-kinase in clathrin-mediated pinocytosis. Understanding this fundamental mechanism of vesicle trafficking could have implications for many diseases.

 

Cytokinesis is the physical separation of two cells that occurs after the completion of mitosis. In this webinar, we will present how we used a combination of optical techniques such as subcellular optogenetics, FRAP, TIRF, confocal imaging (Dragonfly) and SRRF-stream imaging to uncover the membrane dynamics during the final steps of cytokinesis.

 

At the recent 3rd birthday celebration of the Andor Dragonfly confocal system, Dr. Peter March (Bioimaging Facility at The University of Manchester), Biology's answer to Professor Brian Cox, took us on a humorous journey through the life of a Senior Experimental Officer at a growing Bioimaging Facility, including a brief history of Microscopes from the 17th century!

Additional Resources

The Andor Learning Center hosts a wide range of tutorial videos, technical articles and webinars to guide you through the range of products for all your imaging needs. We have provided some links below which will get you started on some of our most recent uploads.

"Dragonfly is an invaluable system for us and the busiest in our core facility. It’s been very helpful for our model organisms and organoid work, as well as being the first system in ESRIC which can do live super-resolution imaging."

Dr Ann Wheeler, Head of Advanced Imaging Resource, IGMM, Edinburgh

"Dragonfly integrates speed of acquisition coupled with little or no photobleaching which has helped me immensely during my mitochondrial imaging. It is a wonderful system to perform both live and fixed cell imaging."

Rajarshi Chakrabarti, PhD, Research Associate at Geisel School of Medicine at Dartmouth