BC43 CF – The Ultimate Benchtop Confocal Microscope

Small in Size, Big in Performance

Andor's Benchtop Confocal delivers amazing images at the push of a button. This plug and play laser confocal system has been designed with cost, performance and accessibility in mind, ensuring hassle-free, high-quality 2D & 3D imaging for busy researchers.

*Microscopy Today 2022 Innovation Award Winner*

BC43 CF: Fast. Easy. Compact. Affordable. This is the future of microscopy. See it in action!

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Fast and Easy Confocal Microscopy in any Lab

BC43 is a super-compact unit that is rich in features and benefits, making it the ideal microscope for early-stage researchers and experienced microscopists alike. With no requirement for a darkroom, researchers can access laser confocal microscopy technology on the same bench as their samples. This, coupled with the fast learning curve, allows individual users and entire labs to become much more productive, without compromising results.

Andor is the first microscope manufacturer to offer an IQ / OQ quality control programme which ensures that all BC43 microscopes operate within tightly controlled parameters, providing confidence that your data and experiments are reproducible in the future.

Click the hotspots below to explore the key features and benefits of Andor BC43 CF.

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Confocal, Widefield & Transmitted Light Microscopy All-In-One

The BC43 benchtop confocal utilizes imaging technology from our award-winning Dragonfly confocal system and provides fast and remarkably flexible imaging. BC43 allows routine imaging from brightfield to confocal without the hassle.

The BC43 system is a pioneer in light microscopy, our IQ/OQ quality control program ensures that all of our microscopes operate within tightly controlled parameters, working with community groups like Quarep-Limi we have a full quality control protocol to ensure the very best performance from your system.

Confocal Microscopy

Capture superb confocal images at least 10 times faster than point scanner-based systems with the Andor Benchtop Confocal!

BC43 is a prime solution for 3D imaging of thick samples. A high sensitivity, high-speed imaging camera makes it perfect for live-cell confocal imaging.

A motorised XY stage allows multiple point acquisition, large organism montages and multipoint scanning resulting in outstanding productivity from a single imaging experiment.

Widefield Fluorescence Microscopy

Widefield imaging:

Offers the gentlest illumination mode for samples that are super-sensitive to light
Detects lower sample signals than in confocal mode
Offers the fastest imaging speeds to capture dynamic processes in live cells

Use ClearView™ GPU to remove sample blur and enhance resolution, ensuring the best quality images.

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Transmitted Light Microscopy

BC43 also delivers two different transmitted light options for amazing imaging flexibility:

Use Brightfield Mode to visualise the development of larger organisms whose structures naturally deliver high contrast images
For thinner samples and/or those with higher transparency, use Differential Phase Contrast (DPC) mode to draw out their structure

You can also mix and match modes like DPC and Widefield for even more imaging flexibility!

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High-Speed Confocal Imaging for Biologists

The BC43 Benchtop Confocal has been developed in collaboration with leading biologists; for use across life science applications, and is designed to be part of a single room workflow. BC43 will bring instant clarity and depth to your research, whatever your sample, in ways previously only found in larger, more complex and expensive imaging systems.

Cancer

BC43 addresses the broad scales and types of imaging protocols and analysis related to cancer research. From subcellular and cellular live cell experiments to large tissue samples and organoids requiring deeper imaging.

Image monolayer and 3D cell cultures.
Follow cell dynamics (intercellular behaviour, migration and division)
High productivity imaging of tissue preparations
Analyse movement, cell lineage, count cells, features and more.
Boost your unit with the Super-resolution module for detailed spatial understanding of actin filaments, microtubule networks, distribution of vesicles and lysosomes etc

Pancreatic ductal adenocarcinoma cells inside and on top of a 3D hydrogel. DNA is blue, lamin A/C is green, and tubulin is orange. Image credit: Sebastian Amos and Yu Suk Choi, University of Western Australia.

Cell Biology

BC43 conquers the diverse range of protocols that Cell Biology experiments demand: from a simple 2D snapshot of a cell to understanding dynamic processes with time-lapse.

BC43's unrivalled clarity and speed will save you time without compromising resolution (X,Y or Z) or field of view.

Confocal mode for fast, high-resolution imaging of tissues
Widefield mode for higher sensitivity and maximum speeds
Built in GPU-based ClearView™ technology boosts image clarity
Boost your unit with the Super-resolution module for detailed spatial understanding of actin filaments, microtubule networks, distribution of vesicles and lysosomes etc,

Core Facilities

Andor’s Benchtop Confocal is a compact, but fully featured system for routine imaging. It can be the imaging workhorse you are looking for, freeing up your sophisticated systems with advanced tools for those who need them.

Simplicity of use has been designed into BC43 to reduce training time and ongoing support of users, enabling labs and facilities to become more efficient.

Researchers will rapidly become competent in acquiring excellent 3D images, and higher multi-dimensional experiments on their own.

Four excitation lines (405, 488, 561 & 640nm)
Up to 5 imaging objectives (exchangeable)
Multiple imaging modes offers flexibility whatever the sample and whatever your budget and needs

Developmental Biology

Cut through the challenges of your 3D world and capture images in perfect clarity - from the very first rounds of cell division to the fully developed organism.

Extract crisp 2D images or explore stunning 3D volumes in a fraction of the time you’re used to. Andor’s Benchtop Confocal delivers fast, high-resolution imaging of developing model organisms such as zebrafish and Drosophila.

Image deeper than conventional fluorescence microscopes
Boost productivity 10-fold compared with traditional confocals
No sacrifices to resolution, field of view or 3D detail for speed

Neuroscience

Break through the burden of countless images demanded by your neuroscience research with a ten-fold speed boost, compared to conventional confocal microscopes. Flexible imaging modes cover sensitive live imaging of neuronal processes to large scale imaging of entire neuronal networks in 3D.

Outstanding real-time 3D visualisation for immediate insight
Discover more imaging live with high temporal resolution
Dedicated image analysis tools with Imaris: automated process tracing, auto depth, spine detection and more
Add super-resolution for fine detailed imaging of neuronal processes.

Tissue Imaging

Capture stunning 2D and 3D images from live tissue models to whole cleared-tissue preparations.

BC43 is a true workhorse instrument for large sample imaging, capturing in a tenth of the time of conventional confocal systems and imaging deeper than widefield epifluorescence with deconvolution or digital clearing.

Time-saving, large-view, high-resolution imaging of tissue.
Capture huge samples with tiled volume imaging and stitching
Innovative analysis tools available with Imaris: machine learning object classification, spatial analysis, volume and morphology and many more.

Powerful and Intuitive Acquisition Software

At the heart of BC43 is a software that is not only feature-rich and flexible to your needs, it is easy-to-use as well:

Imaris rendering engine – stunning real-time 3D images
Clear and concise user-interface – acquire images in no time
Multi-dimensional imaging protocols – advanced 3D time lapse or multi-position montage made easy

Comprehensive Image Analysis Software with AI Tools

All Andor Benchtop Microscopes come with the introductory Imaris Quant package for users to:

Visualise their 2D/3D/4D images in the world’s leading interactive microscopy image analysis software.
Identify and characterize objects within their images via traditional intensity-based and AI methods.
Report counts, morphology metrics, intensity values, and many more statistics to find differences across images and experiments.
Create high-resolution snapshots and multi-dimensional movies with ease.

Additional Imaris modules are also available including tools for tracking and reporting motility metrics, quantifying cells and their intracellular organelles, and tracing neurons for reporting their specific characteristics.

Explore more Confocal Microscopy Imaging Systems

We image high numbers of thick and large tissue samples demanding a reliable confocal microscope to handle big experiments. BC43 is a true workhorse, requiring minimal experience to obtain high quality images. Being able to put it on a regular bench in our own lab is an efficiency bonus!

Professor Jacco van Rheenen, The Netherlands Cancer Institute.

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